UPP’s Global Solutions NetworkUPP’s Global Solutions Network is perpetually on the look-out for items of interest to our expanding ranks of difference-makers. The process is organic in that it matches the unique talents of individuals with specific solution skills to conditions in need of their contributions. Thanks to ever-improving technologies, greater effectiveness is now possible. An outstanding example involves a lethal disease that continues to victimize major populations in under-developed nations: Malaria.
ScienceDaily (Apr. 2, 2010) — Also known as Dengue fever, malaria is transmitted by a virus that threatens 2.5 billion lives each year and imposes immense economic problems. Although quinine treats the symptoms, a more critical challenge is to eliminate the source. Recently researchers at Michigan State University stepped up to the plate. They discovered a bacterium that stymies the culprit before it reaches humans.
"In nature, about 28 percent of mosquito species harbor Wolbachia bacteria, but the mosquitoes that are the primary transmitters of dengue, Aedes aegypti, have no Wolbachia in them," said Zhiyong Xi, MSU assistant professor of entomology. "We found that Wolbachia is able to stop the dengue virus from replicating. If there is no virus in the mosquito, it can't spread to people, so disease transmission can be blocked."
In the April 1 issue of the journal PLoS Pathogens, Xi reports that he and his colleagues introduced the Wolbachia bacterium into Aedes aegypti mosquitoes by injecting embryos. The bacterium then passes to successive generations, producing strains with hostility to the virus. Meanwhile the Wolbachia bacterium itself doesn’t transmit to humans.
An independent report substantiating the success was published by Australian researchers deploying a different variety of the Wolbachia bacterium. "The strain we used has a 100 percent maternal transmission rate and causes the mosquitoes to live slightly longer," Xi explained. "The strain the Australian researchers used causes the mosquitoes to die a bit sooner. There are advantages to both. The longer the mosquitoes live, the more likely they are to pass on the Wolbachia bacteria to their offspring and infect the entire population in a shorter timeframe.
Xi and colleagues, including Guowu Bian, a post-doctoral research associate in Xi's lab who conducted much of the research for this study, are now working to understand how the Wolbachia bacterium stops the dengue virus from replicating in mosquitoes. "Only when we know the mechanisms underlying Wolbachia-mediated viral interference, will we will be able to understand why it's happening and further improve the efficiency of the viral interference," he said.
While dengue fever is rare in the continental United States, Hawaii was the site of a dengue epidemic in 2001. Overall, about one-third of the world's population is exposed. Up to 100 million people are infected each year. While recovery can occur in about two weeks, the risk nevertheless remains for life-threatening consequences marked by bleeding from the nose and gums.
In addition to Xi and Bian, UPP recognizes Yao Xu, visiting pathobiology and diagnostic investigation; Peng Lu, doctoral student in Xi's lab, and Yan Xie, research specialist in the MSU Center for Statistical Training and Consulting. The program is funded by the National Institutes of Health. Xi's research also is supported by the Michigan Agricultural Experiment Station.
Kudos to everyone responsible for bringing forward solutions to cure Malaria.
UPP’s Global Reach
Universal Peace Plan, a 501c3 non-profit, unites people in pursuit of peace with causes to eradicate hunger, poverty, disease, illiteracy, environmental abuses, tyranny and violence. UPP welcomes your participation & ingenuity in creating a multi-cultural, multi-national, multi-lingual initiative that delivers a better world with respect for all. And you delivered! By comparison to the earth with its 7 continents and 196 countries, UPP reaches 6 continents and 92 countries speaking in 22 different languages. Our newest friends come from: Cambodia, Luxembourg and Bolivia. UPP salutes our Facebook friends for building this success story and bridging cultural barriers. Please tell all your FB friends that UPP created Universal Peace Plan –Too because we exceeded our 5,000 friend limit on the original.
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Many solutions to our causes of: hunger, disease, poverty, human rights, economics, literacy and the environment are starting to flood through our site. Check out our wall to read all about the exciting new opportunities for bringing forward correction.
“GETTING IT DONE!”
MAY’S CLOSE UPP: POSITIVE SOLUTIONS SHOWCASE
Shout Out Goes To: WORLD VISION’S “NIGHT OF NETS”
World Vision hosts free music concerts and asks that everyone make a donation of $6 that will buy a bed net for a child living in a Malaria-prone country like Zambia, Mozambique, Kenya and Mali.
Malaria is a mosquito-borne disease that kills nearly one million children every year. Research has shown that bed nets provide one of the best ways to protect children from Malaria.
UPP also recognizes and thanks the Bill and Melinda Gates Foundation for all the great work their foundation does to eradicate Malaria.
BE ROMANTICALLY ENTERTAINED
May’s Feature: Diana Krall “Boy From Ipanema”
Live from Rio
UPP-BEAT ABOUT THE FUTURENon-profits and other research institutions are at the heart of creating solutions for sustainability. As these advancements in the fields for social and environmental security are made known to UPP, we’ll post the great news on our FB wall for all to read. Some will even make it to the UPP Positive Solutions Showcase.
If you now of other organizations that are making a positive difference or if you have proposals to deliver the same, we have an audience eager to discover them. Use UPP to get the word out. Tell us about great work through CONTACT US @upp.org. Great ideas have only come from great minds. The solutions are out there. UPP hopes to reel them in.
In the event that you haven’t read GREATEST 21ST CENTURY EXPERIMENT, click here. It’s worth the read!
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